Covid vaccines, on immunosuppressed children and adolescents do not work well- Corriere.it

from Chiara Daina

The analysis of five studies conducted by researchers at Bambin Gesù Hospital on frail children aged 12 to 25 suggests that the vaccine generates fewer antibodies: they need a personal strategy

In children and adolescents with one weakened immune system The effectiveness of anticovid vaccines may be lower (even absent) compared to healthy peers due to the pathology they suffer from or the effects of the treatments they have to take. They prove it five studies performed by researchers at Bambino Gesù Hospital in Rome on a total sample of 165 frail patients aged between 12 and 25 years.

We need a reinforcement and personal vaccination strategy

Each study analyzes the responses to the first two doses of the Pfizer vaccine in a different group of patients: 21 subjects with primary immunodeficiency, 34 with a heart and lung transplant (namely: 30 heart, two heart and kidney and two other lungs) . 30 with chronic intestinal inflammation, 40 with Down syndrome and just as many with HIV. “For these patients, it is important to intervene with onea reinforcing and personal vaccination strategy – declares Paolo Palma, Head of the Complex Operational Unit for Clinical Immunology and Vaccinology at the Vatican Hospital -. For now, we can rebuild the treatments whenever possible and choose the best type of vaccine to administer among them on the market, depending on the state of health, by establishing any additional doses. The ambition for the future is to study the biological mechanisms that reduce immunity to the virus, in order to be able to produce vaccines that protect these population categories in the light of the results obtained from our studies ”.

Patients with HIV

The studies are part of the “Convers” project and examine both serological immunity (ie the amount of antibodies present in the blood) and cellular immunity to the virus (which consists in the production of T lymphocytes capable of to destroy infected cells). Specifically, all patients with perinatal HIV infection developed specific antibodies to SarsCov2, but in an amount 15 percent lower than the control group.. In 89 percent of the cases, however, there was no production of specific T lymphocytes due to the inflammatory condition induced by HIV and the poor ability of the patient’s immune system to counteract it. The study was published in the journal Clinical infectious diseaseWhile research on subjects with chronic inflammatory disease, published in Vaccines, shows that in patients undergoing treatment based on anti-TNF drugs (monoclonal antibodies), the serological response decreases by 43 percent compared to the group, treated with other immunospressive therapies.

Children with Down syndrome respond as over 65

In children and adolescents with downs Syndromeon the other hand, the number of antibodies developed after the vaccine is the same as for adults over 65 and therefore definitely lower than healthy peers. The starting point for the problem is the premature aging of the immune system that is typical of the syndrome. The study in this case was published in Journal of Clinical Medicine. The fourth study, released it Limits in immunology and related to patients with primary immunodeficiency, highlights that 14 percent of the boys did not produce antibodies after the vaccination course, and 24 percent were without specific T lymphocytes. Again, responsible for the low effectiveness of vaccines is dysfunction of the immune system which characterizes the disease. Finally, the study was edited on Transplantation found that in children they have received a heart or lung transplant the serological reaction is absentIn 31 percent of the cases and in the rest it is less than 95.6 percent compared to healthy peers. And that in three out of ten patients there is also a need to increase anti-SarsCov2 T lymphocytes.

To protect the fragile, keep the stitches

The researchers from The Child Jesus have essentially shown that the majority of immunosuppressed children and adolescents, despite developing a response to the vaccine, have fewer antibodies and fewer T lymphocytes than healthy subjects of the same age and a smaller minority do not . any immunity to Covid. “The next goal of the ‘Convers’ project – Palma concludes – will be to evaluate the maintenance of the vaccination response over time”. Then an appeal in conclusion: “Given the lower effectiveness of current vaccines in these subjects, to protect them, vaccination of both their relatives and the general population and the use of a mask indoors and in situations of social aggregation is crucial In hospitals, waves of Covid patients create a slowdown in the care processes for these fragile categories “.

13 July 2022 (change 13 July 2022 | 16:34)

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