Covid what the study on multisystem inflammatory syndrome in children says

Children with Covid-19 generally have milder symptoms than adults, however, multisystem inflammatory syndrome has occurred in some cases. Now an Australian study has identified the mechanisms. All the details

A study conducted by the Murdoch Children’s Research Institute (MCRI) and the University of Melbourne discovered pathological mechanisms in children with Covid-19 who have multisystem inflammatory syndrome or acute respiratory distress.


In multisystem inflammatory syndrome, various parts of the body can become inflamed, including the heart, lungs, brain, while acute respiratory distress syndrome is a type of lung disease.

Both syndromes are the main potential outcomes of severe Covid-19 in children.

In the Italian case studies, he writes Republicthere were no deaths, but a small percentage of patients had distant cardiac outcomes.


Conor McCafferty, MCRI researcher and PhD student at the University of Melbourne, said the main triggers for severe Covid-19 in children were blood clots and how immune system proteins reacted to the virus.

“In general, children are less susceptible to Covid-19 and have milder symptoms, but the factors that may lead to the development of very serious diseases in some people are not clear,” said McCafferty. “Our research was the first to discover the specific pathways for blood clots and immune proteins that have affected children with Covid-19 who have developed severe symptoms ”.

The team therefore identified the pathways of blood coagulation and immune proteins that are activated in severe cases of Covid-19 in children, thus favoring earlier diagnoses and more targeted treatments.

“Knowing the mechanisms associated with severe Covid-19 in children and knowing how blood coagulation and young children’s immune system respond to the Sars-CoV-2 virus – said Vera Ignjatovic, professor at MCRI – will help recognize acute cases of Covid-19 and will enable us to develop targeted treatment “.


For the study, published it Nature communicationblood samples were collected from 20 healthy children at Royal Children’s Hospital and other samples from 33 Sars-CoV-2 infected children with multisystem inflammatory syndrome or acute respiratory distress syndrome at Necker-Enfants Malades Hospital in Paris.


By comparing the blood samples, the researchers were able to detect that the specific proteins of the multisystem inflammatory syndrome were 85 and those of the acute respiratory distress syndrome 52.

The study then revealed that for 1.7% of hospitalized pediatric Covid-19 patients, it was necessary to resort to intensive care.

Children with multisystem inflammatory syndrome exhibited clinical features similar to Kawasaki’s disease, a syndrome – the cause of which is unknown – that causes generalized inflammation of the blood vessels.


To cure the multisystem-inflammatory syndrome “it usually takes 10 days,” one explained Republic Gian Luigi Marseglia, head of pediatrics at the San Matteo Polyclinic in Pavia, added that “but for some children it is so severe that they require intensive care, especially to ensure cardiovascular function through 24-hour monitoring”.

High-dose steroids and immunoglobulins are given for therapy because, as Marseglia said, “immunoglobulins have an immunomodulatory effect, which, combined with the immunosuppressive effect of cortisone, makes it possible to cure them in all cases”.


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